Chaitan Khosla Selected Research

Protein Glutamine gamma Glutamyltransferase 2

1/2021	An Unusual "OR" Gate for Allosteric Regulation of Mammalian Transglutaminase 2 in the Extracellular Matrix.
11/2017	Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension.
1/2017	Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE.
10/2014	Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
1/2014	Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice.
7/2012	Role of transglutaminase 2 in celiac disease pathogenesis.
4/2012	Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy.
6/2011	Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.
5/2011	Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.
8/2010	Redox regulation of transglutaminase 2 activity.

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Chaitan Khosla Research Topics

Disease

68	Celiac Disease (Celiac Sprue) 01/2022 - 01/2002
13	Neoplasms (Cancer) 01/2020 - 11/2004
10	Inflammation (Inflammations) 01/2022 - 05/2008
5	COVID-19 11/2022 - 01/2021
5	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 09/2002
5	Hypoxia (Hypoxemia) 11/2017 - 03/2009
5	Immune System Diseases (Immune Disorders) 01/2017 - 01/2005
4	Glioblastoma (Glioblastoma Multiforme) 06/2011 - 04/2005
3	Disease Progression 01/2022 - 06/2006
3	Nocardia Infections 01/2021 - 01/2016
3	Atrophy 01/2020 - 04/2010
3	Pulmonary Hypertension 11/2017 - 01/2014
3	Dehydration (Water Stress) 10/2010 - 12/2005
2	Virus Diseases (Viral Diseases) 01/2020 - 01/2017
2	Fibrosis (Cirrhosis) 01/2018 - 11/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 08/2007
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2017 - 03/2005
2	Communicable Diseases (Infectious Diseases) 07/2012 - 11/2004
2	Diarrhea 04/2010 - 02/2008
1	Stuttering (Stammering) 01/2021
1	Pancreatic Diseases (Pancreatic Disease) 01/2017
1	Pathologic Processes 01/2017
1	Abdominal Pain (Pain, Abdominal) 01/2017
1	Reoviridae Infections 01/2017
1	Infections 01/2016
1	Vascular Remodeling 10/2014

Drug/Important Bio-Agent (IBA)

52	Glutens (Glutelin)IBA 01/2022 - 09/2002
23	Peptides (Polypeptides)IBA 01/2022 - 01/2002
22	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2021 - 01/2002
15	EnzymesIBA 01/2021 - 09/2002
13	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2002
8	GliadinIBA 01/2022 - 01/2002
6	Pharmaceutical PreparationsIBA 01/2020 - 04/2006
5	AntibodiesIBA 01/2022 - 07/2005
5	PolyketidesIBA 01/2021 - 11/2004
5	Proline (L-Proline)FDA Link 08/2014 - 03/2004
4	EndopeptidasesIBA 08/2014 - 10/2004
4	KCC 009IBA 06/2011 - 09/2005
3	Polyketide SynthasesIBA 01/2021 - 01/2016
3	Hydro-Lyases (Dehydratases)IBA 01/2021 - 12/2005
3	AntigensIBA 01/2017 - 02/2006
3	Glucose-6-PhosphateIBA 05/2010 - 02/2004
3	Peptide Hydrolases (Proteases)FDA Link 06/2006 - 09/2002
3	EpitopesIBA 02/2006 - 03/2004
3	Prolyl OligopeptidasesIBA 12/2005 - 09/2002
2	favipiravirIBA 11/2022 - 07/2021
2	Messenger RNA (mRNA)IBA 01/2022 - 12/2021
2	Antigen-Antibody Complex (Immune Complex)IBA 01/2022 - 12/2021
2	COVID-19 VaccinesIBA 01/2022 - 12/2021
2	KIR ReceptorsIBA 01/2022 - 12/2021
2	Immunoglobulin G (IgG)IBA 01/2022 - 12/2021
2	CytokinesIBA 01/2022 - 03/2005
2	peginterferon lambda-1aIBA 07/2021 - 01/2021
2	Biological ProductsIBA 01/2021 - 02/2005
2	ALV003IBA 11/2019 - 01/2017
2	DisulfidesIBA 01/2018 - 01/2017
2	Fibronectins (Fibronectin)IBA 11/2017 - 11/2008
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 08/2009
2	Serine Proteases (Serine Protease)IBA 08/2014 - 03/2005
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2013 - 07/2012
2	ProlaminsIBA 05/2008 - 10/2004
2	Cysteine Proteases (Cysteine Protease)IBA 09/2007 - 06/2006
2	Glutamine (L-Glutamine)FDA Link 09/2007 - 06/2006
2	LigandsIBA 02/2006 - 03/2005
2	Carmustine (FIVB)FDA Link 09/2005 - 04/2005
1	VaccinesIBA 01/2022
1	IgG Receptors (Fc gamma RI)IBA 01/2022
1	mRNA VaccinesIBA 12/2021
1	Viral RNAIBA 07/2021
1	Interferon LambdaIBA 01/2021
1	Josamycin (EN 141)IBA 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2020
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2020
1	HLA-DQ8 antigenIBA 01/2020
1	Interleukin-15 (Interleukin 15)IBA 01/2020
1	Disulfiram (Antabuse)FDA Link 01/2018
1	Thiram FDA Link 01/2018
1	ERW1041EIBA 11/2017
1	CollagenIBA 11/2017
1	Semaxinib (SU5416)IBA 11/2017
1	ThioredoxinsIBA 01/2017
1	Cell-Free Nucleic AcidsIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017
1	Calcium-Sensing ReceptorsIBA 10/2014
1	Transient Receptor Potential ChannelsIBA 10/2014
1	CalciumIBA 10/2014
1	Transcription Factors (Transcription Factor)IBA 10/2014
1	Serotonin (5 Hydroxytryptamine)IBA 01/2014
1	Immunosuppressive Agents (Immunosuppressants)IBA 08/2013
1	Simvastatin (Zocor)FDA LinkGeneric 08/2013
1	Interleukin-17 (Interleukin 17)IBA 04/2013
1	Interleukin-22 (IL-22)IBA 04/2013
1	Erythromycin (Erycette)FDA LinkGeneric 07/2012
1	MacrolidesIBA 07/2012

Therapy/Procedure

15	Therapeutics 01/2021 - 09/2002
5	Gluten-Free Diet 11/2019 - 01/2012
4	Enzyme Therapy 01/2012 - 10/2002
2	Drug Therapy (Chemotherapy) 06/2011 - 09/2005
2	Aftercare (After-Treatment) 06/2011 - 11/2008